Potensi Quercetin Sebagai Agen Antidiabetes Pada Model Tikus Diabetes Mellitus Tipe 2: Tinjauan Literatur Sistematis
Article Sidebar
Submitted
13 April 2026
Published
30 July 2026
Keywords:
-
Antidiabetes, Diabetes Mellitus Tipe 2, Quercetin
Abstract
Diabetes mellitus (DM) is metabolic disorder characterized by elevated blood sugar levels due to insulin dysfunction. Research on natural compounds as alternative therapies is growing, one of which is quercetin which is known to have antidiabetic effects. This study aims to analyze the scientific literature related to the potential of quercetin as an antidiabetic in a rat model of type 2 diabetes mellitus. The method used in this study was a systematic literature review using the PRISMA approach, with data obtained from two main databases, Google Scholar and Pubmed, from 2015 to 2026. A search using the keywords “quercetin”, “type 2 diabetes”, and “rats”. From the total articles identified, five studies met the final inclusion criteria and were analyzed. The results showed that quercetin has a role in lowering blood sugar levels, improving insulin levels, and has a protective effect on pancreatic ?-cell damage. However, the available evidence remains limited to animal studies, and further clinical research is required before the findings can be generalized to humans or applied as a therapeutic option for diabetes management.
References
Abdou, H. M., Hamaad, F. A., Ali, E. Y., & Ghoneum, M. H. (2022). Biomedicine & Pharmacotherapy Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomedicine & Pharmacotherapy, 149, 112838. https://doi.org/10.1016/j.biopha.2022.112838
Adler, A., Bennett, P., Colagiuri, S., Gregg, E., Tandon, N., Unwin, N., Wild, S., & Yudkin, J. (2021). WITHDRAWN?: Reprint of?: Classification of diabetes mellitus q. https://doi.org/10.1016/j.diabres.2021.108972
Ansari, P., Choudhury, S. T., Seidel, V., Rahman, A. Bin, Aziz, A., Richi, A. E., Rahman, A., Jafrin, U. H., Hannan, J. M. A., & Abdel-wahab, Y. H. A. (2022). Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus. 1–18.
Azeem, M., Hanif, M., & Mahmood, K. (2023). a review. Polymer Bulletin, 80(1), 241–262. https://doi.org/10.1007/s00289-022-04091-8
Dhanya, R. (2022). Biomedicine & Pharmacotherapy Quercetin for managing type 2 diabetes and its complications , an insight into multitarget therapy. Biomedicine & Pharmacotherapy, 146, 112560. https://doi.org/10.1016/j.biopha.2021.112560
Goyal R, Singhal M, Jialal I. Type 2 Diabetes (2023). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513253/
Günal, D., & Capanoglu, E. (2025). Quercetin: Potential antidiabetic effects through enzyme inhibition and starch digestibility. August 2024, 9–22. https://doi.org/10.1002/fsh3.12066
Ju, Z., Li, M., Xu, J., Howell, D. C., Li, Z., & Chen, F. (2022). Recent development on COX-2 inhibitors as promising anti-inflammatory agents?: The past 10 years. Acta Pharmaceutica Sinica B, 12(6), 2790–2807. https://doi.org/10.1016/j.apsb.2022.01.002
Kementerian Kesehatan RI, 2023. Hasil Survei Kesehatan Indonesia 2023.
Ke, R. Q., Wang, Y., Hong, S. H., Xiao, L. X., City, G., & Province, J. (2023). Anti Diabetic Efect of Quercetin in Type 2 Diabetes Mellitus by Regulating The microRNA-92B-3P/EGR1 Axis. 41, 149–158. https://doi.org/10.26402/jpp.2023.2.03
Magliano, D. J., & Boyko, E. J. (2022). IDF diabetes atlas.
Michala, A. S., & Pritsa, A. (2022). Quercetin?: A Molecule of Great Biochemical and Clinical Value.
Oyedemi, S. O., Nwaogu, G., Chukwuma, C. I., Adeyemi, O. T., Matsabisa, M. G., Swain, S. S., & Aiyegoro, O. A. (2019). Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats?: In silico studies of molecular interaction of quercetin with hexokinase and catalase. May, 1–16. https://doi.org/10.1111/jfbc.13127
Rahmani, A. H., Alsahli, M. A., & Khan, A. A. (2023). Quercetin , a Plant Flavonol Attenuates Diabetic Complications , Renal Tissue Damage , Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.
Shaikhomar, O. A., & Bahattab, O. S. (2021). Physiological Effect of Quercetin as a Natural Flavonoid to be used as Hypoglycemic Agent in Diabetes Mellitus Type II Rats. 3214, 10–17. https://doi.org/10.36348/sjbr.2021.v06i01.0033
Shi, G., Li, Y., Cao, Q., Wu, H., Tang, X., & Gao, X. (2019). Biomedicine & Pharmacotherapy In vitro and in vivo evidence that quercetin protects against diabetes and its complications?: A systematic review of the literature. Biomedicine & Pharmacotherapy, 109(October 2018), 1085–1099. https://doi.org/10.1016/j.biopha.2018.10.130
Srinivasan, P., Vijayakumar, S., Kothandaraman, S., & Palani, M. (2018). Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L . fruit?: In silico and in vivo approaches. Journal of Pharmaceutical Analysis, 8(2), 109–118. https://doi.org/10.1016/j.jpha.2017.10.005
Trakooncharoenvit, A., Hara, H., & Hira, T. (2021). Combination of ? ? Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide ? 1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet. https://doi.org/10.1021/acs.jafc.1c01388
Trinh, N. T., Yamashita, T., Ohneda, K., Kimura, K., Salazar, G. T. A., Sato, F., & Ohneda, O. (2016).Increased Expression of EGR-1 in Diabetic Human. 25(10), 760–773. https://doi.org/10.1089/scd.2015.0335
Wang, L., Geng, J., Sun, B., Sun, C., Shi, Y., & Yu, X. (2020). MiR-92b-3p is Induced by Advanced Glycation End Products and Involved in the Pathogenesis of Diabetic Nephropathy. 2020
Adler, A., Bennett, P., Colagiuri, S., Gregg, E., Tandon, N., Unwin, N., Wild, S., & Yudkin, J. (2021). WITHDRAWN?: Reprint of?: Classification of diabetes mellitus q. https://doi.org/10.1016/j.diabres.2021.108972
Ansari, P., Choudhury, S. T., Seidel, V., Rahman, A. Bin, Aziz, A., Richi, A. E., Rahman, A., Jafrin, U. H., Hannan, J. M. A., & Abdel-wahab, Y. H. A. (2022). Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus. 1–18.
Azeem, M., Hanif, M., & Mahmood, K. (2023). a review. Polymer Bulletin, 80(1), 241–262. https://doi.org/10.1007/s00289-022-04091-8
Dhanya, R. (2022). Biomedicine & Pharmacotherapy Quercetin for managing type 2 diabetes and its complications , an insight into multitarget therapy. Biomedicine & Pharmacotherapy, 146, 112560. https://doi.org/10.1016/j.biopha.2021.112560
Goyal R, Singhal M, Jialal I. Type 2 Diabetes (2023). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513253/
Günal, D., & Capanoglu, E. (2025). Quercetin: Potential antidiabetic effects through enzyme inhibition and starch digestibility. August 2024, 9–22. https://doi.org/10.1002/fsh3.12066
Ju, Z., Li, M., Xu, J., Howell, D. C., Li, Z., & Chen, F. (2022). Recent development on COX-2 inhibitors as promising anti-inflammatory agents?: The past 10 years. Acta Pharmaceutica Sinica B, 12(6), 2790–2807. https://doi.org/10.1016/j.apsb.2022.01.002
Kementerian Kesehatan RI, 2023. Hasil Survei Kesehatan Indonesia 2023.
Ke, R. Q., Wang, Y., Hong, S. H., Xiao, L. X., City, G., & Province, J. (2023). Anti Diabetic Efect of Quercetin in Type 2 Diabetes Mellitus by Regulating The microRNA-92B-3P/EGR1 Axis. 41, 149–158. https://doi.org/10.26402/jpp.2023.2.03
Magliano, D. J., & Boyko, E. J. (2022). IDF diabetes atlas.
Michala, A. S., & Pritsa, A. (2022). Quercetin?: A Molecule of Great Biochemical and Clinical Value.
Oyedemi, S. O., Nwaogu, G., Chukwuma, C. I., Adeyemi, O. T., Matsabisa, M. G., Swain, S. S., & Aiyegoro, O. A. (2019). Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats?: In silico studies of molecular interaction of quercetin with hexokinase and catalase. May, 1–16. https://doi.org/10.1111/jfbc.13127
Rahmani, A. H., Alsahli, M. A., & Khan, A. A. (2023). Quercetin , a Plant Flavonol Attenuates Diabetic Complications , Renal Tissue Damage , Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.
Shaikhomar, O. A., & Bahattab, O. S. (2021). Physiological Effect of Quercetin as a Natural Flavonoid to be used as Hypoglycemic Agent in Diabetes Mellitus Type II Rats. 3214, 10–17. https://doi.org/10.36348/sjbr.2021.v06i01.0033
Shi, G., Li, Y., Cao, Q., Wu, H., Tang, X., & Gao, X. (2019). Biomedicine & Pharmacotherapy In vitro and in vivo evidence that quercetin protects against diabetes and its complications?: A systematic review of the literature. Biomedicine & Pharmacotherapy, 109(October 2018), 1085–1099. https://doi.org/10.1016/j.biopha.2018.10.130
Srinivasan, P., Vijayakumar, S., Kothandaraman, S., & Palani, M. (2018). Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L . fruit?: In silico and in vivo approaches. Journal of Pharmaceutical Analysis, 8(2), 109–118. https://doi.org/10.1016/j.jpha.2017.10.005
Trakooncharoenvit, A., Hara, H., & Hira, T. (2021). Combination of ? ? Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide ? 1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet. https://doi.org/10.1021/acs.jafc.1c01388
Trinh, N. T., Yamashita, T., Ohneda, K., Kimura, K., Salazar, G. T. A., Sato, F., & Ohneda, O. (2016).Increased Expression of EGR-1 in Diabetic Human. 25(10), 760–773. https://doi.org/10.1089/scd.2015.0335
Wang, L., Geng, J., Sun, B., Sun, C., Shi, Y., & Yu, X. (2020). MiR-92b-3p is Induced by Advanced Glycation End Products and Involved in the Pathogenesis of Diabetic Nephropathy. 2020
Authors
Ananda, R. A. A. D. (2026). Potensi Quercetin Sebagai Agen Antidiabetes Pada Model Tikus Diabetes Mellitus Tipe 2: Tinjauan Literatur Sistematis. Jurnal Kesehatan Marendeng, 10(2), 131–143. https://doi.org/10.58554/jkm.v10i2.217
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.